Search results for "antidiabetic agent"

showing 6 items of 6 documents

Requirements for claims of favorable effects on serum lipids by oral antidiabetic agents.

1998

Blood GlucoseMalemedicine.medical_specialtymedicine.medical_treatmentBlood lipidsHyperlipidemiasBioinformaticsDiabetes ComplicationsOral administrationInternal medicineDiabetes mellitusmedicineDiabetes MellitusHumansHypoglycemic AgentsAntidiabetic agentsChemotherapybusiness.industryDrugs Investigationalmedicine.diseaseLipidsEndocrinologyCardiologyFemaleCardiology and Cardiovascular MedicinebusinessThe American journal of cardiology
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1,2,4-OSSADIAZOLI: UTILI SCAFFOLD NEL DESIGN DI NUOVI FARMACI

2021

quinazolinone(di)-acylguanidineneuroprotective agentreduction124-Oxadiazoleantidiabetic agentSARS-CoV2 proteaseSettore CHIM/06 - Chimica Organica
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2-(4-Toluidino)pyrimidine

1984

Aus der Kondensation von 4-Tolylguanidin (1) mil den β-Diketonen 2a-g gehen die 2-(4-Toluidino)pyrimidine 3a-g hervor, unter denen sich Vertreter mit antidiabetischer und antimykotischer Wirksamkeit befinden. Antidiabetic Agents, II: 2-(4-Toluidino)pyrimidines Condensations of 4-tolylguanidine (1) with the β-diketones 2a-g yield the 2-(4-toluidino)pyrimidines 3a-g which comprise compounds exhibiting antidiabetic and antimycotic activities.

Diketonechemistry.chemical_compoundPyrimidineChemistryStereochemistryYield (chemistry)AcetylacetoneDrug DiscoveryPharmaceutical ScienceAliphatic compoundMedicinal chemistryAntidiabetic agentsArchiv der Pharmazie
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Diabetes and Colorectal Cancer Risk: A New Look at Molecular Mechanisms and Potential Role of Novel Antidiabetic Agents.

2021

Epidemiological data have demonstrated a significant association between the presence of type 2 diabetes mellitus (T2DM) and the development of colorectal cancer (CRC). Chronic hyperglycemia, insulin resistance, oxidative stress, and inflammation, the processes inherent to T2DM, also play active roles in the onset and progression of CRC. Recently, small dense low-density lipoprotein (LDL) particles, a typical characteristic of diabetic dyslipidemia, emerged as another possible underlying link between T2DM and CRC. Growing evidence suggests that antidiabetic medications may have beneficial effects in CRC prevention. According to findings from a limited number of preclinical and clinical stud…

Oncologyendocrine system diseasesColorectal cancerComorbidityReview0302 clinical medicineinsulin resistanceEpidemiologyBiology (General)small dense LDLSpectroscopyglucagon-like peptide-1 receptor agonists0303 health sciencesIncidenceGeneral MedicineSmall dense LDL3. Good healthComputer Science ApplicationsLipoproteins LDLChemistry030220 oncology & carcinogenesismedicine.symptomColorectal Neoplasmsmedicine.medical_specialtyQH301-705.5InflammationCatalysisGlucagon-like peptide-1 receptor agonistsGlucagon-Like Peptide-1 ReceptorInorganic Chemistry03 medical and health sciencesInsulin resistanceInternal medicineDiabetes mellitusmedicineHumansHypoglycemic AgentsIn patientPhysical and Theoretical ChemistryQD1-999Molecular BiologyAntidiabetic agents030304 developmental biologyInflammationbusiness.industryOrganic ChemistryType 2 Diabetes Mellitusnutritional and metabolic diseasesInsulin resistanceGlucagon-like peptide-1 receptor agonists Hyperglycemia Inflammation Insulin resistance Comorbidity Diabetes Mellitus Type 2 Glucagon-Like Peptide-1 Receptor Humans Hyperglycemia Hypoglycemic Agents Incidence Lipoproteins LDL Oxidative Stress Colorectal Neoplasms Small dense LDLmedicine.diseasedigestive system diseasesOxidative StressDiabetes Mellitus Type 2Oxidative stressinflammationHyperglycemiabusinessInternational journal of molecular sciences
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Use of Novel Antidiabetic Agents in Patients with Type 2 Diabetes and COVID-19: A Critical Review

2021

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19). The latter is a pandemic that has the potential of developing into a severe illness manifesting as systemic inflammatory response syndrome, acute respiratory distress syndrome, multi-organ involvement and shock. In addition, advanced age and male sex and certain underlying health conditions, like type 2 diabetes mellitus (T2DM), predispose to a higher risk of greater COVID-19 severity and mortality. This calls for an urgent identification of antidiabetic agents associated with more favourable COVID-19 outcomes among patients with T2DM, as well as recognition of their potential underlying…

medicine.medical_specialtyCoronavirus disease 2019 (COVID-19)1 receptor agonists Sodium-glucose co-transporter&nbspEndocrinology Diabetes and MetabolismSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)COVID-19 Dipeptidyl peptidase&nbspReviewType 2 diabetesSodium-glucose co-transporter 2 inhibitorsType 2 diabetesGlucagon-like peptide 1 receptor agonistsDiabetes mellitusPandemicInternal Medicinemedicine2 diabetesIntensive care medicineAntidiabetic agents4 inhibitors Glucagon-like peptide&nbspbusiness.industryCOVID-19medicine.diseaseSystemic inflammatory response syndromeShock (circulatory)Dipeptidyl peptidase 4 inhibitorsmedicine.symptombusiness2 inhibitors Type&nbspDiabetes Therapy
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Dietary polyphenols as antidiabetic agents: Advances and opportunities

2020

Abstract Dietary polyphenols have been widely investigated as antidiabetic agents in cell, animals, human study, and clinical trial. The number of publication (Indexed by Web of Science) on “polyphenols and diabetes” significantly increased since 2010. This review highlights the advances and opportunities of dietary polyphenols as antidiabetic agents. Dietary polyphenols prevent and manage Type 2 diabetes mellitus via the insulin‐dependent approaches, for instance, protection of pancreatic islet β‐cell, reduction of β‐cell apoptosis, promotion of β‐cell proliferation, attenuation of oxidative stress, activation of insulin signaling, and stimulation of pancreas to secrete insulin, as well as…

bioavailability clinical study diabetes diabetic complication dietary polyphenols glucose absorption intestinal microbiota pancreatic islet -celldiabetesNutrition. Foods and food supplybusiness.industrydietary polyphenolsfood and beveragesdiabetic complicationclinical studyTP368-456Pharmacologymedicine.diseaseFood processing and manufactureGlucose absorptionBioavailabilityClinical studyglucose absorptionDiabetic complicationPolyphenolDiabetes mellitusmedicineTX341-641bioavailabilitybusinessAntidiabetic agentsFood Frontiers
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